Multi-scale models for the optimization of batch bioreactors
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In this paper, we propose multi-scale models for a batch bioreactor, which are developed by expanding the so-called Herbert's Microbial Kinetics (HMK) concept so that the effects of mixing conditions are incorporated via the inclusion of the aeration rate and stirrer speed into the microbial kinetics. By using the multi-scale models, we are able to optimize the batch bioreactor's performances, i.e. yield and productivity, by adjusting the aeration rate and stirrer speed. Simulation and experimental studies on a batch (fermentation) bioreactor demonstrate the application of this approach, whereby the integration of the expanded HMK model with the Computational Fluid Dynamics (CFD) model of mixing, which we call it as a Kinetics Multi-Scale (KMS) model, is able to predict the experimental values of yield and productivity of the batch fermentation process accurately (with less than 5% errors). © 2012 IFAC.
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Liew, Emily Wan Teng (2011)Mixing plays a substantial role in determining the overall performance of a bioreactor. Well mixing in bioreactor, especially for ethanolic fermentation process is important for the homogenization of miscible and immiscible ...
Liew, Emily; Nandong, Jobrun; Samyudia, Yudi (2012)In this paper, we propose multi-scale models for a batch bioreactor, which are developed by expanding the so-called Herbert’s Microbial Kinetics (HMK) concept so that the effects of mixing conditions are incorporated via ...
Liew, Emily; Nandong, Jobrun; Samyudia, Yudi (2013)Process models play an important role in the bioreactor design, optimisation and control. In previous work, the bioreactor models have mainly been developed by considering the microbial kinetics and the reactor environmental ...