Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Family history and the natural history of colorectal cancer: Systematic review

    Access Status
    Open access via publisher
    Authors
    Henrikson, N.
    Webber, E.
    Goddard, K.
    Scrol, A.
    Piper, M.
    Williams, M.
    Zallen, D.
    Calonge, N.
    Ganiats, T.
    Janssens, A.
    Zauber, A.
    Lansdorp_Vogelaar, Iris
    Van Ballegooijen, M.
    Whitlock, E.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Henrikson, N. and Webber, E. and Goddard, K. and Scrol, A. and Piper, M. and Williams, M. and Zallen, D. et al. 2015. Family history and the natural history of colorectal cancer: Systematic review. Genetics in Medicine. 17 (9): pp. 702-712.
    Source Title
    Genetics in Medicine
    DOI
    10.1038/gim.2014.188
    ISSN
    1098-3600
    URI
    http://hdl.handle.net/20.500.11937/48910
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks. Methods: We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening. Results: We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC. Conclusion: Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history-based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.

    Related items

    Showing items related by title, author, creator and subject.

    • Rationale and design of the European Polyp Surveillance (EPoS) trials
      Jover, R.; Bretthauer, M.; Dekker, E.; Holme, O.; Kaminski, M.; Loberg, M.; Zauber, A.; Hernán, M.; Lansdorp-Vogelaar, Iris; Sunde, A.; McFadden, E.; Castells, A.; Regula, J.; Quintero, E.; Pellisé, M.; Senore, C.; Kalager, M.; Dinis-Ribeiro, M.; Emilsson, L.; Ransohoff, D.; Hoff, G.; Adami, H. (2016)
      Background: Current guidelines recommend surveillance colonoscopies after polyp removal depending on the number and characteristics of polyps, but there is a lack of evidence supporting the recommendations. This report ...
    • Association between family cancer history and risk of pancreatic cancer.
      Schulte, A.; Pandeya, N.; Fawcett, J.; Fritschi, Lin; Klein, K.; Risch, H.; Webb, P.; Whiteman, D.; Neale, R. (2016)
      PURPOSE: Family history of pancreatic adenocarcinoma is an established risk factor for the disease. However, associations of pancreatic cancer with other familial cancers are less clear. We analyzed data from the Queensland ...
    • Developing a score chart to improve risk stratification of patients with colorectal adenoma
      Van Heijningen, E.; Lansdorp_Vogelaar, Iris; Van Hees, F.; Kuipers, E.; Biermann, K.; De Koning, H.; Van Ballegooijen, M.; Steyerberg, E. (2016)
      Background and study aims: Current surveillance guidelines risk stratify patients with adenoma by using only one or two factors: adenoma multiplicity or presence of an advanced adenoma characteristic. Combinations of ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.