Show simple item record

dc.contributor.authorBremner, A.
dc.contributor.authorFeddema, P.
dc.contributor.authorLeedman, P.
dc.contributor.authorBrown, S.
dc.contributor.authorBeilby, J.
dc.contributor.authorLim, E.
dc.contributor.authorWilson, S.
dc.contributor.authorO'Leary, Peter
dc.contributor.authorWalsh, J.
dc.identifier.citationBremner, A. and Feddema, P. and Leedman, P. and Brown, S. and Beilby, J. and Lim, E. and Wilson, S. et al. 2012. Age-related changes in thyroid function: a longitudinal study of a community-based cohort. Journal of Clinical Endocrinology and Metabolism. 97 (5): pp. 1554-1562.

Context: In cross-sectional studies, serum TSH concentrations increase with age. This has not beenexamined longitudinally, and it is uncertain whether the TSH increase reflects healthy aging oroccult thyroid failure.Methods: We measured serum TSH, free T4, thyroid peroxidase, and thyroglobulin antibodies in1100 participants in the 1981 and 1994 Busselton Health Surveys and derived a reference group of908 individuals without thyroid disease or thyroid antibodies. We examined changes in thyroidfunction longitudinally and, in 781 participants, explored associations with the CAPZB polymorphismrs10917469.Results: At 13 yr follow-up, mean serum TSH increased from 1.49 to 1.81 mU/liter, a change in meanTSH (TSH) of 0.32 mU/liter [95% confidence interval (CI) 0.27, 0.38, P0.001], whereas mean freeT4 concentration was unchanged (16.6 vs. 16.6 pmol/liter, P 0.7). The TSH increase was mostmarked in the elderly, such that gender-adjusted TSH increased by 0.08 mU/liter (95% CI 0.04,0.11) for each decade of baseline age. People with higher baseline TSH values had proportionallysmaller increases in TSH, with each additional 1.0 mU/liter of baseline TSH associated with a 0.13mU/liter decrease (age and gender adjusted) in TSH (95% CI 0.09, 0.16). The TSH did not differsignificantly by CAPZB genotype.Conclusions: Aging is associated with increased serum TSH concentrations, with no change in freeT4 concentrations. The largest TSH increase is in people with the lowest TSH at baseline. Thissuggests that the TSH increase arises from age-related alteration in the TSH set point or reducedTSH bioactivity rather than occult thyroid disease. (J Clin Endocrinol Metab 97: 0000–0000, 2012)

dc.publisherEndocrine Society
dc.subjectBusselton health study
dc.subjectlongitudinal study
dc.subjectthyroid stimulating hormone (TSH)
dc.titleAge-related changes in thyroid function: a longitudinal study of a community-based cohort
dc.typeJournal Article
dcterms.source.titleJournal of Clinical Endocrinology and Metabolism
curtin.departmentCentre for Population Health Research
curtin.accessStatusFulltext not available

Files in this item


This item appears in the following Collection(s)

Show simple item record