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    Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications

    Grenik E 2016.pdf (2.957Mb)
    Access Status
    Open access
    Authors
    Grenik, Elizabeth Monica
    Date
    2016
    Supervisor
    Prof. Xia Lou
    Prof. Deirdre Coombe
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Science and Engineering
    School
    Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/49779
    Collection
    • Curtin Theses
    Abstract

    Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed on the hydrogels with HS which enhanced myoblast differentiation. This was likely due to the improved cell organisation from cell-hydrogel interactions. The improved cell behaviour on the modified hydrogels showed potential for tissue regeneration.

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