Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications
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Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed on the hydrogels with HS which enhanced myoblast differentiation. This was likely due to the improved cell organisation from cell-hydrogel interactions. The improved cell behaviour on the modified hydrogels showed potential for tissue regeneration.
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