Chemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applications
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Access Status
Open access
Authors
Grenik, Elizabeth Monica
Date
2016Supervisor
Prof. Xia Lou
Prof. Deirdre Coombe
Type
Thesis
Education Level
Ph.D.
Metadata
Show full item recordAbstract
Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed on the hydrogels with HS which enhanced myoblast differentiation. This was likely due to the improved cell organisation from cell-hydrogel interactions. The improved cell behaviour on the modified hydrogels showed potential for tissue regeneration.
Faculty
Science and Engineering
Department
Chemical Engineering
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