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dc.contributor.authorGrenik, Elizabeth Monica
dc.contributor.supervisorProf. Xia Louen_US
dc.contributor.supervisorProf. Deirdre Coombeen_US
dc.date.accessioned2017-03-28T04:26:22Z
dc.date.available2017-03-28T04:26:22Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/20.500.11937/49779
dc.description.abstract

Heparan sulfate (HS) and RGD were immobilised on porous 3D poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels. Significantly improved adhesion and proliferation of fibroblasts and myoblasts was demonstrated after the covalent immobilisation of the biomolecules. The best cell behaviour was observed on the hydrogels with HS which enhanced myoblast differentiation. This was likely due to the improved cell organisation from cell-hydrogel interactions. The improved cell behaviour on the modified hydrogels showed potential for tissue regeneration.

en_US
dc.publisherCurtin Universityen_US
dc.titleChemical Modification of PHEMA to Create an Improved Bioactive Biomaterial for Regenerative Applicationsen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentChemical Engineeringen_US
curtin.accessStatusOpen accessen_US
curtin.facultyScience and Engineeringen_US


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