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    Measuring neuroplasticity associated with cerebral palsy rehabilitation: An MRI based power analysis

    Access Status
    Fulltext not available
    Authors
    Reid, L.
    Pagnozzi, A.
    Fiori, S.
    Boyd, Roslyn
    Dowson, N.
    Rose, S.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Reid, L. and Pagnozzi, A. and Fiori, S. and Boyd, R. and Dowson, N. and Rose, S. 2017. Measuring neuroplasticity associated with cerebral palsy rehabilitation: An MRI based power analysis. International Journal of Developmental Neuroscience. 58: pp. 17-25.
    Source Title
    International Journal of Developmental Neuroscience
    DOI
    10.1016/j.ijdevneu.2017.01.010
    ISSN
    0736-5748
    School
    School of Occupational Therapy and Social Work
    URI
    http://hdl.handle.net/20.500.11937/50497
    Collection
    • Curtin Research Publications
    Abstract

    Researchers in the field of child neurology are increasingly looking to supplement clinical trials of motor rehabilitation with neuroimaging in order to better understand the relationship between behavioural training, brain changes, and clinical improvements. Randomised controlled trials are typically accompanied by sample size calculations to detect clinical improvements but, despite the large cost of neuroimaging, not equivalent calculations for concurrently acquired imaging neuroimaging measures of changes in response to intervention. To aid in this regard, a power analysis was conducted for two measures of brain changes that may be indexed in a trial of rehabilitative therapy for cerebral palsy: cortical thickness of the impaired primary sensorimotor cortex, and fractional anisotropy of the impaired, delineated corticospinal tract. Power for measuring fractional anisotropy was assessed for both region-of-interest-seeded and fMRI-seeded diffusion tractography. Taking into account practical limitations, as well as data loss due to behavioural and image-processing issues, estimated required participant numbers were 101, 128 and 59 for cortical thickness, region-of-interest-based tractography, and fMRI-seeded tractography, respectively. These numbers are not adjusted for study attrition. Although these participant numbers may be out of reach of many trials, several options are available to improve statistical power, including careful preparation of participants for scanning using mock simulators, careful consideration of image processing options, and enrolment of as homogeneous a cohort as possible. This work suggests that smaller and moderate sized studies give genuine consideration to harmonising scanning protocols between groups to allow the pooling of data.

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