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dc.contributor.authorTochhawng, L.
dc.contributor.authorDeng, S.
dc.contributor.authorPervaiz, Shazib
dc.contributor.authorYap, C.
dc.date.accessioned2017-03-17T08:28:53Z
dc.date.available2017-03-17T08:28:53Z
dc.date.created2017-02-19T19:31:45Z
dc.date.issued2013
dc.identifier.citationTochhawng, L. and Deng, S. and Pervaiz, S. and Yap, C. 2013. Redox regulation of cancer cell migration and invasion. Mitochondrion. 13 (3): pp. 246-253.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/50882
dc.identifier.doi10.1016/j.mito.2012.08.002
dc.description.abstract

Cancer cell migration and invasion are the initial steps in metastasis. Through a series of cellular events, including cytoskeletal remodeling resulting in phenotype changes and degradation of the extracellular matrix, cells are able to detach from the primary tumor and metastasize to distant sites. These changes occur in response to intracellular signaling mechanisms triggered via cell surface receptor stimulation or signal amplification within the cell. Amongst the active molecules that participate in relaying cellular signals are the reactive oxygen species (ROS). Initially identified to participate in defense mechanisms to ward off invading pathogens, ROS are now considered to have important roles in several other biological processes including cancer development. In this report, we review recent evidence pointing towards the involvement of ROS in tumor progression. We discuss the biology of ROS and their roles at different stages during the process of cancer cell migration and invasion. © 2012 Elsevier B.V. and Mitochondria Research Society.

dc.publisherElsevier
dc.titleRedox regulation of cancer cell migration and invasion
dc.typeJournal Article
dcterms.source.volume13
dcterms.source.number3
dcterms.source.startPage246
dcterms.source.endPage253
dcterms.source.issn1567-7249
dcterms.source.titleMitochondrion
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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