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    Adenine nucleotide translocase family: Four isoforms for apoptosis modulation in cancer

    Access Status
    Open access via publisher
    Authors
    Brenner, C.
    Subramaniam, K.
    Pertuiset, C.
    Pervaiz, Shazib
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Brenner, C. and Subramaniam, K. and Pertuiset, C. and Pervaiz, S. 2011. Adenine nucleotide translocase family: Four isoforms for apoptosis modulation in cancer. Oncogene. 30 (8): pp. 883-895.
    Source Title
    Oncogene
    DOI
    10.1038/onc.2010.501
    ISSN
    0950-9232
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/50963
    Collection
    • Curtin Research Publications
    Abstract

    Mitochondria have important functions in mammalian cells as the energy powerhouse and integrators of the mitochondrial pathway of apoptosis. The adenine nucleotide translocase (ANT) is a family of proteins involved in cell death pathways that perform distinctly opposite functions to regulate cell fate decisions. On the one hand, ANT catalyzes the adenosine triphosphate export from the mitochondrial matrix to the intermembrane space with the concomitant import of ADP from the intermembrane space to the matrix. On the other hand, during periods of stress, ANT could function as a lethal pore and trigger the process of mitochondrial membrane permeabilization, which leads irreversibly to cell death. In human, ANT is encoded by four homologous genes, whose expression is not only tissue specific, but also varies according to the pathophysiological state of the cell. Recent evidence revealed a differential role of the ANT isoforms in apoptosis and a deregulation of their expression in cancer. In this review, we introduce the current knowledge of ANT in apoptosis and cancer cells and propose a novel classification of ANT isoforms. © 2011 Macmillan Publishers Limited All rights reserved.

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