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dc.contributor.authorBrenner, C.
dc.contributor.authorSubramaniam, K.
dc.contributor.authorPertuiset, C.
dc.contributor.authorPervaiz, Shazib
dc.date.accessioned2017-03-17T08:29:11Z
dc.date.available2017-03-17T08:29:11Z
dc.date.created2017-02-19T19:31:45Z
dc.date.issued2011
dc.identifier.citationBrenner, C. and Subramaniam, K. and Pertuiset, C. and Pervaiz, S. 2011. Adenine nucleotide translocase family: Four isoforms for apoptosis modulation in cancer. Oncogene. 30 (8): pp. 883-895.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/50963
dc.identifier.doi10.1038/onc.2010.501
dc.description.abstract

Mitochondria have important functions in mammalian cells as the energy powerhouse and integrators of the mitochondrial pathway of apoptosis. The adenine nucleotide translocase (ANT) is a family of proteins involved in cell death pathways that perform distinctly opposite functions to regulate cell fate decisions. On the one hand, ANT catalyzes the adenosine triphosphate export from the mitochondrial matrix to the intermembrane space with the concomitant import of ADP from the intermembrane space to the matrix. On the other hand, during periods of stress, ANT could function as a lethal pore and trigger the process of mitochondrial membrane permeabilization, which leads irreversibly to cell death. In human, ANT is encoded by four homologous genes, whose expression is not only tissue specific, but also varies according to the pathophysiological state of the cell. Recent evidence revealed a differential role of the ANT isoforms in apoptosis and a deregulation of their expression in cancer. In this review, we introduce the current knowledge of ANT in apoptosis and cancer cells and propose a novel classification of ANT isoforms. © 2011 Macmillan Publishers Limited All rights reserved.

dc.publisherNature Publishing Group
dc.titleAdenine nucleotide translocase family: Four isoforms for apoptosis modulation in cancer
dc.typeJournal Article
dcterms.source.volume30
dcterms.source.number8
dcterms.source.startPage883
dcterms.source.endPage895
dcterms.source.issn0950-9232
dcterms.source.titleOncogene
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


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