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    Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

    Access Status
    Open access via publisher
    Authors
    Indran, I.
    Tufo, G.
    Pervaiz, Shazib
    Brenner, C.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Indran, I. and Tufo, G. and Pervaiz, S. and Brenner, C. 2011. Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. BBA - Bioenergetics. 1807 (6): pp. 735-745.
    Source Title
    BBA - Bioenergetics
    DOI
    10.1016/j.bbabio.2011.03.010
    ISSN
    0005-2728
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51262
    Collection
    • Curtin Research Publications
    Abstract

    Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells. This article is part of a Special Issue entitled: Bioenergetics of Cancer. © 2011 Published by Elsevier B.V.

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