Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy

Patel, Kunal; Raj, B.; Chen, Yan; Lou, Xia

doi:10.1016/j.colsurfb.2016.10.045

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Authors

Patel, Kunal

Raj, B.

Chen, Yan

Lou, Xia

Date

2017

Type

Journal Article

Metadata

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Citation

Patel, K. and Raj, B. and Chen, Y. and Lou, X. 2017. Novel folic acid conjugated Fe3O4-ZnO hybrid nanoparticles for targeted photodynamic therapy. Colloids and Surfaces B: Biointerfaces. 150: pp. 317-325.

Source Title

Colloids and Surfaces B: Biointerfaces

DOI

10.1016/j.colsurfb.2016.10.045

ISSN

0927-7765

School

Nanochemistry Research Institute

URI

http://hdl.handle.net/20.500.11937/51281

Collection

Curtin Research Publications

Abstract

© 2016 Elsevier B.V.A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produced nano-PSs, due to the charge recombination via electron trapping by dissolved Fe3+. A time and dose dependant toxicity associated with the nano-PSs was observed upon exposure to human epithelial colorectal adenocarcinoma (Caco-2) cells in the dark. UV irradiation of the synthesised nano-PSs resulted in a significant photo-killing effect with drastic reduction in Caco-2 cell viability to as low as 6%. Reduction in viability upon exposure was due fundamentally to cellular interactions with light irradiated PSs as the influence of radiation alone was subtracted. FA conjugation further enhanced the photo-killing effect.