Novel folic acid conjugated Fe<inf>3</inf>O<inf>4</inf>-ZnO hybrid nanoparticles for targeted photodynamic therapy
|dc.identifier.citation||Patel, K. and Raj, B. and Chen, Y. and Lou, X. 2017. Novel folic acid conjugated Fe<inf>3</inf>O<inf>4</inf>-ZnO hybrid nanoparticles for targeted photodynamic therapy. Colloids and Surfaces B: Biointerfaces. 150: pp. 317-325.|
© 2016 Elsevier B.V.A novel folic acid conjugated core-shell hybrid iron oxide-zinc oxide nanoparticle was developed for applications as a photosensitier (PS) in photodynamic therapy. Photodegradation studies on methylene blue demonstrated significantly enhanced photophysical properties of the produced nano-PSs, due to the charge recombination via electron trapping by dissolved Fe3+. A time and dose dependant toxicity associated with the nano-PSs was observed upon exposure to human epithelial colorectal adenocarcinoma (Caco-2) cells in the dark. UV irradiation of the synthesised nano-PSs resulted in a significant photo-killing effect with drastic reduction in Caco-2 cell viability to as low as 6%. Reduction in viability upon exposure was due fundamentally to cellular interactions with light irradiated PSs as the influence of radiation alone was subtracted. FA conjugation further enhanced the photo-killing effect.
|dc.title||Novel folic acid conjugated Fe<inf>3</inf>O<inf>4</inf>-ZnO hybrid nanoparticles for targeted photodynamic therapy|
|dcterms.source.title||Colloids and Surfaces B: Biointerfaces|
|curtin.department||Nanochemistry Research Institute|
|curtin.accessStatus||Fulltext not available|
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