Angiotensin receptor neprilysin inhibitor LCZ696: Pharmacology, pharmacokinetics and clinical development
MetadataShow full item record
© 2017 Future Medicine Ltd.Heart failure still has a significant disease burden with poor outcomes worldwide despite advances in therapy. The standard therapies have been focused on blockade of renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and mineralocorticoid antagonists and the sympathetic nervous system with ß-blockers. The natriuretic peptide system is a potential counter-regulatory system that promotes vasodilatation and natriuresis. Angiotensin receptor neprilysin inhibitors are a new class drug capable of blocking the renin-angiotensin-aldosterone system and enhancing the natriuretic peptide system to improve neurohormonal balance. The success of the PARADIGM-HF trial with LCZ696 and its approval for heart failure treatment is likely to generate a paradigm shift. This review summarises the current knowledge of LCZ696 with a focus on pharmacology, pharmacokinetics and pharmacodynamics, mechanisms of action, clinical efficacy and safety.
Showing items related by title, author, creator and subject.
Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatmentKadowaki, D.; Sakaguchi, S.; Miyamoto, Y.; Taguchi, K.; Muraya, N.; Narita, Y.; Sato, K.; Chuang, Victor; Maruyama, T.; Otagiri, M.; Hirata, S. (2015)Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide adenine dinucleotide ...
Owen, A.; Reid, Christopher (2012)Amlodipine is a long-acting, dihydropyridine calcium antagonist now widely used for lowering of elevated blood pressure. In recent years it has been shown to be effective in reducing both blood pressure and risk of ...
Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors.John, S.; Thangapandian, S.; Arooj, Mahreen; Hong, J.; Kim, K.; Lee, K. (2011)Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first and rate-limiting ...