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dc.contributor.authorHua, Y.
dc.contributor.authorWang, I.
dc.contributor.authorLiu, B.
dc.contributor.authorKelly, D.
dc.contributor.authorReid, Christopher
dc.contributor.authorLiew, D.
dc.contributor.authorZhou, Y.
dc.contributor.authorWang, B.
dc.date.accessioned2017-03-24T11:53:08Z
dc.date.available2017-03-24T11:53:08Z
dc.date.created2017-03-23T06:59:51Z
dc.date.issued2017
dc.identifier.citationHua, Y. and Wang, I. and Liu, B. and Kelly, D. and Reid, C. and Liew, D. and Zhou, Y. et al. 2017. Angiotensin receptor neprilysin inhibitor LCZ696: Pharmacology, pharmacokinetics and clinical development. Future Cardiology. 13 (2): pp. 103-115.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/51401
dc.identifier.doi10.2217/fca-2016-0057
dc.description.abstract

© 2017 Future Medicine Ltd.Heart failure still has a significant disease burden with poor outcomes worldwide despite advances in therapy. The standard therapies have been focused on blockade of renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and mineralocorticoid antagonists and the sympathetic nervous system with ß-blockers. The natriuretic peptide system is a potential counter-regulatory system that promotes vasodilatation and natriuresis. Angiotensin receptor neprilysin inhibitors are a new class drug capable of blocking the renin-angiotensin-aldosterone system and enhancing the natriuretic peptide system to improve neurohormonal balance. The success of the PARADIGM-HF trial with LCZ696 and its approval for heart failure treatment is likely to generate a paradigm shift. This review summarises the current knowledge of LCZ696 with a focus on pharmacology, pharmacokinetics and pharmacodynamics, mechanisms of action, clinical efficacy and safety.

dc.titleAngiotensin receptor neprilysin inhibitor LCZ696: Pharmacology, pharmacokinetics and clinical development
dc.typeJournal Article
dcterms.source.volume13
dcterms.source.number2
dcterms.source.startPage103
dcterms.source.endPage115
dcterms.source.issn1479-6678
dcterms.source.titleFuture Cardiology
curtin.departmentDepartment of Health Policy and Management
curtin.accessStatusFulltext not available


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