An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy
MetadataShow full item record
This thesis showed that specialised immune cells, dendritic cells and T cells, that play a key role in protecting us from cancer become increasingly dysfunctional (suppressive) during aging, which is exacerbated by cancer. Moreover, anti-cancer chemotherapy and immunotherapy promote even more suppressive dendritic cells and T cells, which may explain reduced treatment efficacy in the elderly. The data suggest that combining chemotherapy and/or immunotherapy with strategies to alleviate immunosuppression may improve elderly cancer patient outcomes.
Showing items related by title, author, creator and subject.
Schaefer, Rainer (2008)At present, most cancers are treated with surgery, radiotherapy and chemotherapy, used alone or in combination. Surgery and radiotherapy are the primary treatment modalities after early detection of cancers and they ...
Synergistic anti-cancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) and doxorubicin using micellar nanoparticlesLee, A.; Dhillon, S.; Wang, Y.; Pervaiz, Shazib; Fan, W.; Yang, Y. (2011)The use of small molecule drugs in cancer chemotherapy has mostly been limited by dose-dependent toxicity and development of drug resistance resulting from repeated administrations. To overcome such problems, efforts have ...
Brestovac, Brian; Townsend, D.; Snook, J.; Ellison, Gaewyn; Phillips, A. (2013)There is a need for cancer treatments to be selectively cytotoxic to cancer cells so as to reduce adverse side effects. In this study, a cancer cell line (HeLa cells) and a non-cancer cell line (HF-32) were exposed to an ...