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    An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy

    Gardner J 2016.pdf (161.8Mb)
    Access Status
    Open access
    Authors
    Gardner, Joanne Karina
    Date
    2016
    Supervisor
    Prof. Delia Nelson
    Dr Connie Jackaman
    Assoc. Prof. Cyril Mamotte
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51694
    Collection
    • Curtin Theses
    Abstract

    This thesis showed that specialised immune cells, dendritic cells and T cells, that play a key role in protecting us from cancer become increasingly dysfunctional (suppressive) during aging, which is exacerbated by cancer. Moreover, anti-cancer chemotherapy and immunotherapy promote even more suppressive dendritic cells and T cells, which may explain reduced treatment efficacy in the elderly. The data suggest that combining chemotherapy and/or immunotherapy with strategies to alleviate immunosuppression may improve elderly cancer patient outcomes.

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