An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy
| dc.contributor.author | Gardner, Joanne Karina | |
| dc.contributor.supervisor | Prof. Delia Nelson | en_US |
| dc.contributor.supervisor | Dr Connie Jackaman | en_US |
| dc.contributor.supervisor | Assoc. Prof. Cyril Mamotte | en_US |
| dc.date.accessioned | 2017-03-28T03:37:58Z | |
| dc.date.available | 2017-03-28T03:37:58Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/51694 | |
| dc.description.abstract |
This thesis showed that specialised immune cells, dendritic cells and T cells, that play a key role in protecting us from cancer become increasingly dysfunctional (suppressive) during aging, which is exacerbated by cancer. Moreover, anti-cancer chemotherapy and immunotherapy promote even more suppressive dendritic cells and T cells, which may explain reduced treatment efficacy in the elderly. The data suggest that combining chemotherapy and/or immunotherapy with strategies to alleviate immunosuppression may improve elderly cancer patient outcomes. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | An increase in suppressive dendritic cells and T cells is a hallmark of healthy aging, a phenomenon exacerbated by cancer and modulated by chemo‐ and immunotherapy | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | Biomedical Sciences | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |