View Item 

A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions

Access Status
Open access
Authors
Klenner, Mitchell
Pascali, G.
Zhang, B.
Sia, T.
Spare, L.
Krause-Heuer, A.
Aldrich-Wright, J.
Greguric, I.
Guastella, A.
Massi, Massimiliano
Fraser, B.
Date
2017
Type
Journal Article

Metadata
Show full item record
Citation
Klenner, M. and Pascali, G. and Zhang, B. and Sia, T. and Spare, L. and Krause-Heuer, A. and Aldrich-Wright, J. et al. 2017. A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions. Chemistry: A European Journal. 23 (27): pp. 6499-6503.
Source Title
Chemistry: A European Journal
DOI
ISSN
School
Department of Chemistry
URI
Collection
Abstract

Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.