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dc.contributor.authorKlenner, Mitchell
dc.contributor.authorPascali, G.
dc.contributor.authorZhang, B.
dc.contributor.authorSia, T.
dc.contributor.authorSpare, L.
dc.contributor.authorKrause-Heuer, A.
dc.contributor.authorAldrich-Wright, J.
dc.contributor.authorGreguric, I.
dc.contributor.authorGuastella, A.
dc.contributor.authorMassi, Massimiliano
dc.contributor.authorFraser, B.
dc.date.accessioned2017-04-28T13:57:33Z
dc.date.available2017-04-28T13:57:33Z
dc.date.created2017-04-28T09:06:03Z
dc.date.issued2017
dc.identifier.citationKlenner, M. and Pascali, G. and Zhang, B. and Sia, T. and Spare, L. and Krause-Heuer, A. and Aldrich-Wright, J. et al. 2017. A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions. Chemistry: A European Journal. 23 (27): pp. 6499-6503.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/52113
dc.identifier.doi10.1002/chem.201700440
dc.description.abstract

Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.

dc.publisherWiley - V C H Verlag GmbH & Co. KGaA
dc.titleA Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions
dc.typeJournal Article
dcterms.source.issn1521-3765
dcterms.source.titleChemistry: A European Journal
curtin.departmentDepartment of Chemistry
curtin.accessStatusOpen access


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