A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions
| dc.contributor.author | Klenner, Mitchell | |
| dc.contributor.author | Pascali, G. | |
| dc.contributor.author | Zhang, B. | |
| dc.contributor.author | Sia, T. | |
| dc.contributor.author | Spare, L. | |
| dc.contributor.author | Krause-Heuer, A. | |
| dc.contributor.author | Aldrich-Wright, J. | |
| dc.contributor.author | Greguric, I. | |
| dc.contributor.author | Guastella, A. | |
| dc.contributor.author | Massi, Massimiliano | |
| dc.contributor.author | Fraser, B. | |
| dc.date.accessioned | 2017-04-28T13:57:33Z | |
| dc.date.available | 2017-04-28T13:57:33Z | |
| dc.date.created | 2017-04-28T09:06:03Z | |
| dc.date.issued | 2017 | |
| dc.identifier.citation | Klenner, M. and Pascali, G. and Zhang, B. and Sia, T. and Spare, L. and Krause-Heuer, A. and Aldrich-Wright, J. et al. 2017. A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions. Chemistry: A European Journal. 23 (27): pp. 6499-6503. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/52113 | |
| dc.identifier.doi | 10.1002/chem.201700440 | |
| dc.description.abstract |
Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes. | |
| dc.publisher | Wiley - V C H Verlag GmbH & Co. KGaA | |
| dc.title | A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions | |
| dc.type | Journal Article | |
| dcterms.source.issn | 1521-3765 | |
| dcterms.source.title | Chemistry: A European Journal | |
| curtin.department | Department of Chemistry | |
| curtin.accessStatus | Open access |