Inversion-based propofol dosing for intravenous induction of hypnosis

Padula, Fabrizio; Ionescu, C.; Latronico, N.; Paltenghi, M.; Visioli, A.; Vivacqua, G.

doi:10.1016/j.cnsns.2016.04.003

Access Status

Fulltext not available

Authors

Padula, Fabrizio

Ionescu, C.

Latronico, N.

Paltenghi, M.

Visioli, A.

Vivacqua, G.

Date

2016

Type

Journal Article

Metadata

Show full item record

Citation

Padula, F. and Ionescu, C. and Latronico, N. and Paltenghi, M. and Visioli, A. and Vivacqua, G. 2016. Inversion-based propofol dosing for intravenous induction of hypnosis. Communications in Nonlinear Science and Numerical Simulation. 39: pp. 481-494.

Source Title

Communications in Nonlinear Science and Numerical Simulation

DOI

10.1016/j.cnsns.2016.04.003

ISSN

1007-5704

School

Department of Mathematics and Statistics

URI

http://hdl.handle.net/20.500.11937/52197

Collection

Curtin Research Publications

Abstract

© 2016 Elsevier B.V.In this paper we propose an inversion-based methodology for the computation of a feedforward action for the propofol intravenous administration during the induction of hypnosis in general anesthesia. In particular, the typical initial bolus is substituted with a command signal that is obtained by predefining a desired output and by applying an input-output inversion procedure. The robustness of the method has been tested by considering a set of patients with different model parameters, which is representative of a large population.