Diverse mobilization strategies facilitate transfer of non-conjugative mobile genetic elements
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Conjugation is a dominant mechanism of horizontal gene transfer and substantially contributes to the plasticity and evolvability of prokaryotic genomes. The impact of conjugation on genetic flux extends well beyond self-transmissible conjugative elements, because non-conjugative ‘mobilizable elements’ utilize other elements’ conjugative apparatus for transfer. Bacterial genome comparisons highlight plasmids as vehicles for dissemination of pathogenesis and antimicrobial-resistance determinants, but for most non-conjugative plasmids, a mobilization mechanism is not apparent. Recently we discovered many Staphylococcus aureus plasmids lacking mobilization genes carry oriT sequences that mimic those on conjugative plasmids, suggesting that significantly more elements may be mobilizable than previously recognized. Here we summarize our findings, review the diverse mobilization strategies employed by mobile genetic elements and discuss implications for future gene-transfer research.
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Pollet, R.; Ingle, J.; Hymes, J.; Eakes, T.; Eto, K.; Kwong, S.; Ramsay, Joshua; Firth, N.; Redinbo, M. (2016)Antimicrobial resistance in Staphylococcus aureus presents an increasing threat to human health. This resistance is often encoded on mobile plasmids, such as pSK41; however, the mechanism of transfer of these plasmids is ...
Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolatesO'Brien, Frances; Ramsay, J.; Monecke, S.; Coombs, Geoffrey; Robinson, O.; Htet, Z.; Alshaikh, F.; Grubb, W. (2015)Objectives: To describe a family of conjugative plasmids isolated from colonizing community Staphylococcus aureus and determine their ability to mobilize unrelated antimicrobial resistance/virulence plasmids, not encoding ...