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    Diverse mobilization strategies facilitate transfer of non-conjugative mobile genetic elements

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    Authors
    Ramsay, Joshua
    Firth, N.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Ramsay, J. and Firth, N. 2017. Diverse mobilization strategies facilitate transfer of non-conjugative mobile genetic elements. Current Opinion in Microbiology. 38: pp. 1-9.
    Source Title
    Current Opinion in Microbiology
    DOI
    10.1016/j.mib.2017.03.003
    ISSN
    1369-5274
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/53172
    Collection
    • Curtin Research Publications
    Abstract

    Conjugation is a dominant mechanism of horizontal gene transfer and substantially contributes to the plasticity and evolvability of prokaryotic genomes. The impact of conjugation on genetic flux extends well beyond self-transmissible conjugative elements, because non-conjugative ‘mobilizable elements’ utilize other elements’ conjugative apparatus for transfer. Bacterial genome comparisons highlight plasmids as vehicles for dissemination of pathogenesis and antimicrobial-resistance determinants, but for most non-conjugative plasmids, a mobilization mechanism is not apparent. Recently we discovered many Staphylococcus aureus plasmids lacking mobilization genes carry oriT sequences that mimic those on conjugative plasmids, suggesting that significantly more elements may be mobilizable than previously recognized. Here we summarize our findings, review the diverse mobilization strategies employed by mobile genetic elements and discuss implications for future gene-transfer research.

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