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dc.contributor.authorRamsay, Joshua
dc.contributor.authorFirth, N.
dc.date.accessioned2017-06-23T02:58:58Z
dc.date.available2017-06-23T02:58:58Z
dc.date.created2017-06-19T03:39:28Z
dc.date.issued2017
dc.identifier.citationRamsay, J. and Firth, N. 2017. Diverse mobilization strategies facilitate transfer of non-conjugative mobile genetic elements. Current Opinion in Microbiology. 38: pp. 1-9.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/53172
dc.identifier.doi10.1016/j.mib.2017.03.003
dc.description.abstract

Conjugation is a dominant mechanism of horizontal gene transfer and substantially contributes to the plasticity and evolvability of prokaryotic genomes. The impact of conjugation on genetic flux extends well beyond self-transmissible conjugative elements, because non-conjugative ‘mobilizable elements’ utilize other elements’ conjugative apparatus for transfer. Bacterial genome comparisons highlight plasmids as vehicles for dissemination of pathogenesis and antimicrobial-resistance determinants, but for most non-conjugative plasmids, a mobilization mechanism is not apparent. Recently we discovered many Staphylococcus aureus plasmids lacking mobilization genes carry oriT sequences that mimic those on conjugative plasmids, suggesting that significantly more elements may be mobilizable than previously recognized. Here we summarize our findings, review the diverse mobilization strategies employed by mobile genetic elements and discuss implications for future gene-transfer research.

dc.titleDiverse mobilization strategies facilitate transfer of non-conjugative mobile genetic elements
dc.typeJournal Article
dcterms.source.volume38
dcterms.source.startPage1
dcterms.source.endPage9
dcterms.source.issn1369-5274
dcterms.source.titleCurrent Opinion in Microbiology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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