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    Role of NF-κB in tumorigenesis

    Access Status
    Fulltext not available
    Authors
    Shanmugam, M.
    Kumar, Alan Prem
    Tan, B.
    Sethi, G.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Shanmugam, M. and Kumar, A.P. and Tan, B. and Sethi, G. 2013. Role of NF-κB in tumorigenesis. Forum on Immunopathological Diseases and Therapeutics. 4 (2): pp. 181-196.
    Source Title
    Forum on Immunopathological Diseases and Therapeutics
    DOI
    10.1615/ForumImmunDisTher.2013008382
    ISSN
    2151-8017
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/53174
    Collection
    • Curtin Research Publications
    Abstract

    Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer.

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