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    Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes

    200463_200463.pdf (1.501Mb)
    Access Status
    Open access
    Authors
    Mooranian, Armin
    Negrulj, Rebecca
    Al-Sallami, H.
    Fang, Zhongxiang
    Mikov, Momir
    Golocorbin-Kon, S.
    Fakhoury, M.
    Watts, G.
    Matthews, V.
    Arfuso, Frank
    Lambros, Amanda
    Al-Salami, Hani
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mooranian, A. and Negrulj, R. and Al-Sallami, H. and Fang, Z. and Mikov, M. and Golocorbin-Kon, S. and Fakhoury, M. et al. 2014. Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes. AAPS PharmSciTech. 16 (1): pp. 45-52.
    Source Title
    AAPS PharmSciTech
    DOI
    10.1208/s12249-014-0205-9
    ISSN
    1530-9932
    School
    School of Pharmacy
    Remarks

    The final publication is available at Springer via http://doi.org/10.1208/s12249-014-0205-9

    URI
    http://hdl.handle.net/20.500.11937/5324
    Collection
    • Curtin Research Publications
    Abstract

    In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new microencapsulated formulation of probucol-sodium alginate (PB-SA), with good structural properties and excipient compatibility. The aim of this study was to examine the stability and pH-dependent targeted release of the microcapsules at various pH values and different temperatures. Microencapsulation was carried out using a Büchi-based microencapsulating system developed in our laboratory. Using SA polymer, two formulations were prepared: empty SA microcapsules (SA, control) and loaded SA microcapsules (PB-SA, test), at a constant ratio (1:30), respectively. Microcapsules were examined for drug content, zeta potential, size, morphology and swelling characteristics and PB release characteristics at pH 1.5, 3, 6 and 7.8. The production yield and microencapsulation efficiency were also determined. PB-SA microcapsules had 2.6 ± 0.25% PB content, and zeta potential of −66 ± 1.6%, suggesting good stability. They showed spherical and uniform morphology and significantly higher swelling at pH 7.8 at both 25 and 37°C (p < 0.05). The microcapsules showed multiphasic release properties at pH 7.8. The production yield and microencapsulation efficiency were high (85 ± 5 and 92 ± 2%, respectively). The PB-SA microcapsules exhibited distal gastrointestinal tract targeted delivery with a multiphasic release pattern and with good stability and uniformity. However, the release of PB from the microcapsules was not controlled, suggesting uneven distribution of the drug within the microcapsules.

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    • Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes
      Mooranian, A.; Negrulj, R.; Al-Sallami, H.; Fang, Zhongxiang; Mikov, M.; Golocorbin-Kon, S.; Fakhoury, M.; Watts, G.; Matthews, V.; Arfuso, Frank; Lambros, A.; Al-Salami, Hani (2014)
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      Mooranian, A.; Negrulj, R.; Arfuso, Frank; Al-Salami, Hani (2015)
      In recent studies, we designed multi-compartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in an animal model of type 2 diabetes (T2D). Probucol (PB) is a highly lipophilic, ...
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      Negrulj, R.; Mooranian, A.; Chen-Tan, N.; Al-Sallami, H.; Mikov, M.; Golocorbin-Kon, S.; Fakhoury, M.; Watts, G.; Arfuso, Frank; Al-Salami, H. (2015)
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