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    Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain

    Huda N 2017.pdf (5.578Mb)
    Access Status
    Open access
    Authors
    Huda, Naz Hasan
    Date
    2017
    Supervisor
    Dr Yan Chen
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/54102
    Collection
    • Curtin Theses
    Abstract

    The development of a biocompatible dual ligand PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate drug delivery system to enhance delivery into the brain. Nanoparticulate formulations containing the drug rivastigmine had physicochemical characteristics ideal for targeting the brain and negligible cytotoxicity. Cell uptake and transport were superior to the drug solution or nanoparticles without the ligand targeting technology. This dual ligand NP drug delivery system is a potential platform technology for brain delivery for a range of therapeutic outcomes.

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