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dc.contributor.authorHuda, Naz Hasan
dc.contributor.supervisorDr Yan Chenen_US
dc.date.accessioned2017-07-04T06:07:48Z
dc.date.available2017-07-04T06:07:48Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/20.500.11937/54102
dc.description.abstract

The development of a biocompatible dual ligand PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate drug delivery system to enhance delivery into the brain. Nanoparticulate formulations containing the drug rivastigmine had physicochemical characteristics ideal for targeting the brain and negligible cytotoxicity. Cell uptake and transport were superior to the drug solution or nanoparticles without the ligand targeting technology. This dual ligand NP drug delivery system is a potential platform technology for brain delivery for a range of therapeutic outcomes.

en_US
dc.publisherCurtin Universityen_US
dc.titleDevelopment of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brainen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentPharmacyen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US


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