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    Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection

    Access Status
    Open access via publisher
    Authors
    Simpson, S.
    Ranganathan, S.
    Park, J.
    Turkovic, L.
    Robins-Browne, R.
    Skoric, B.
    Ramsey, K.
    Rosenow, T.
    Banton, G.
    Berry, L.
    Stick, S.
    Hall, Graham
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Simpson, S. and Ranganathan, S. and Park, J. and Turkovic, L. and Robins-Browne, R. and Skoric, B. and Ramsey, K. et al. 2015. Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection. European Respiratory Journal. 46 (6): pp. 1680-1690.
    Source Title
    European Respiratory Journal
    DOI
    10.1183/13993003.00622-2015
    ISSN
    0903-1936
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/54812
    Collection
    • Curtin Research Publications
    Abstract

    Measures of ventilation distribution are promising for monitoring early lung disease in cystic fibrosis (CF). This study describes the cross-sectional and longitudinal impacts of pulmonary inflammation and infection on ventilation homogeneity in infants with CF. Infants diagnosed with CF underwent multiple breath washout (MBW) testing and bronchoalveolar lavage at three time points during the first 2 years of life. Measures were obtained for 108 infants on 156 occasions. Infants with a significant pulmonary infection at the time of MBW showed increases in lung clearance index (LCI) of 0.400 units (95% CI 0.150–0.648; p=0.002). The impact was long lasting, with previous pulmonary infection leading to increased ventilation inhomogeneity over time compared to those who remained free of infection (p<0.05). Infection with Haemophilus influenzae was particularly detrimental to the longitudinal lung function in young children with CF where LCI was increased by 1.069 units for each year of life (95% CI 0.484–1.612; p<0.001). Pulmonary infection during the first year of life is detrimental to later lung function. Therefore, strategies aimed at prevention, surveillance and eradication of pulmonary pathogens are paramount to preserve lung function in infants with CF.

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