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    Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis

    Access Status
    Fulltext not available
    Authors
    Ramsey, K.
    Foong, R.
    Grdosic, J.
    Harper, A.
    Skoric, B.
    Clem, C.
    Davis, M.
    Turkovic, L.
    Stick, S.
    Davis, S.
    Ranganathan, S.
    Hall, Graham
    Date
    2017
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
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    Abstract

    © 2017 by the American Thoracic Society. Rationale: The lung clearance index is a measure of ventilation distribution derived from the multiple-breath washout technique. The lung clearance index is increased in the presence of lower respiratory tract inflammation and infection in infants with cystic fibrosis; however, the associations during the preschool years are unknown. Objectives: We assessed the ability of the lung clearance index to detect the presence and extent of lower respiratory tract inflammation and infection in preschool children with cystic fibrosis. Methods: Ventilation distribution outcomes were assessed at 82 visits with 58 children with cystic fibrosis and at 38 visits with 31 healthy children aged 3-6 years. Children with cystic fibrosis also underwent bronchoalveolar lavage fluid collection for detection of lower respiratory tract inflammation and infection. Associations between multiple-breath washout indices and the presence and extent of airway inflammation and infection were assessed using linear mixed effects models. Results: Lung clearance index was elevated in children with cystic fibrosis (mean [SD], 8.00 [1.45] ) compared with healthy control subjects (6.67 [0.56]). In cystic fibrosis, the lung clearance index was elevated in individuals with lower respiratory tract infections (difference compared with uninfected [95% confidence interval] , 0.62 [0.06, 1.18]) and correlated with the extent of airway inflammation. Conclusions: These data suggest that the lung clearance index may be a useful surveillance tool for monitoring the presence and extent of lower airway inflammation and infection in preschool children with cystic fibrosis.

    Citation
    Ramsey, K. and Foong, R. and Grdosic, J. and Harper, A. and Skoric, B. and Clem, C. and Davis, M. et al. 2017. Multiple-breath washout outcomes are sensitive to inflammation and infection in children with cystic fibrosis. Annals of the American Thoracic Society. 14 (9): pp. 1436-1442.
    Source Title
    Annals of the American Thoracic Society
    URI
    http://hdl.handle.net/20.500.11937/58865
    DOI
    10.1513/AnnalsATS.201611-935OC
    Department
    School of Physiotherapy and Exercise Science

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