Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes

Glushkov, V.; Stryapunina, O.; Dolzhenko, Anton; Syropyatov, B.; Shklyaev, Y.

doi:10.1007/s11094-009-0284-1

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Authors

Glushkov, V.

Stryapunina, O.

Dolzhenko, Anton

Syropyatov, B.

Shklyaev, Y.

Date

2009

Type

Journal Article

Metadata

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Citation

Glushkov, V. and Stryapunina, O. and Dolzhenko, Anton and Syropyatov, B. and Shklyaev, Y. 2009. Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes. Pharmaceutical Chemistry Journal. 43 (5): pp. 245-248.

Source Title

Pharmaceutical Chemistry Journal

DOI

10.1007/s11094-009-0284-1

ISSN

0091-150X

School

School of Pharmacy

URI

http://hdl.handle.net/20.500.11937/5503

Collection

Curtin Research Publications

Abstract

Three-component condensation of veratrole, isobutylene oxide, and aliphatic omega-chloronitriles via the Ritter reaction leads to 1-(omega-chloroalkyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity.