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dc.contributor.authorGlushkov, V.
dc.contributor.authorStryapunina, O.
dc.contributor.authorDolzhenko, Anton
dc.contributor.authorSyropyatov, B.
dc.contributor.authorShklyaev, Y.
dc.date.accessioned2017-01-30T10:46:37Z
dc.date.available2017-01-30T10:46:37Z
dc.date.created2011-08-18T20:01:07Z
dc.date.issued2009
dc.identifier.citationGlushkov, V. and Stryapunina, O. and Dolzhenko, Anton and Syropyatov, B. and Shklyaev, Y. 2009. Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes. Pharmaceutical Chemistry Journal. 43 (5): pp. 245-248.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/5503
dc.identifier.doi10.1007/s11094-009-0284-1
dc.description.abstract

Three-component condensation of veratrole, isobutylene oxide, and aliphatic omega-chloronitriles via the Ritter reaction leads to 1-(omega-chloroalkyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity.

dc.publisherSpringer
dc.titleSynthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes
dc.typeJournal Article
dcterms.source.volume43
dcterms.source.number5
dcterms.source.startPage245
dcterms.source.endPage248
dcterms.source.issn0091-150X
dcterms.source.titlePharmaceutical Chemistry Journal
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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