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    Geographic variation in the eukaryotic virome of human diarrhea

    Access Status
    Open access via publisher
    Authors
    Holtz, L.
    Cao, S.
    Zhao, G.
    Bauer, I.
    Denno, D.
    Klein, E.
    Antonio, M.
    Stine, O.
    Snelling, Thomas
    Kirkwood, C.
    Wang, D.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Holtz, L. and Cao, S. and Zhao, G. and Bauer, I. and Denno, D. and Klein, E. and Antonio, M. et al. 2014. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 468: pp. 556-564.
    Source Title
    Virology
    DOI
    10.1016/j.virol.2014.09.012
    ISSN
    0042-6822
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/55393
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 Elsevier Inc. Little is known about the population of eukaryotic viruses in the human gut ("virome") or the potential role it may play in disease. We used a metagenomic approach to define and compare the eukaryotic viromes in pediatric diarrhea cohorts from two locations (Melbourne and Northern Territory, Australia). We detected viruses known to cause diarrhea, non-pathogenic enteric viruses, viruses not associated with an enteric reservoir, viruses of plants, and novel viruses. Viromes from Northern Territory children contained more viral families per sample than viromes from Melbourne, which could be attributed largely to an increased number of sequences from the families Adenoviridae and Picornaviridae (genus enterovirus). qRT-PCR/PCR confirmed the increased prevalence of adenoviruses and enteroviruses. Testing of additional diarrhea cohorts by qRT-PCR/PCR demonstrated statistically different prevalences in different geographic sites. These findings raise the question of whether the virome plays a role in enteric diseases and conditions that vary with geography.

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