Show simple item record

dc.contributor.authorHoltz, L.
dc.contributor.authorCao, S.
dc.contributor.authorZhao, G.
dc.contributor.authorBauer, I.
dc.contributor.authorDenno, D.
dc.contributor.authorKlein, E.
dc.contributor.authorAntonio, M.
dc.contributor.authorStine, O.
dc.contributor.authorSnelling, Thomas
dc.contributor.authorKirkwood, C.
dc.contributor.authorWang, D.
dc.date.accessioned2017-08-24T02:18:25Z
dc.date.available2017-08-24T02:18:25Z
dc.date.created2017-08-23T07:21:45Z
dc.date.issued2014
dc.identifier.citationHoltz, L. and Cao, S. and Zhao, G. and Bauer, I. and Denno, D. and Klein, E. and Antonio, M. et al. 2014. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 468: pp. 556-564.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/55393
dc.identifier.doi10.1016/j.virol.2014.09.012
dc.description.abstract

© 2014 Elsevier Inc. Little is known about the population of eukaryotic viruses in the human gut ("virome") or the potential role it may play in disease. We used a metagenomic approach to define and compare the eukaryotic viromes in pediatric diarrhea cohorts from two locations (Melbourne and Northern Territory, Australia). We detected viruses known to cause diarrhea, non-pathogenic enteric viruses, viruses not associated with an enteric reservoir, viruses of plants, and novel viruses. Viromes from Northern Territory children contained more viral families per sample than viromes from Melbourne, which could be attributed largely to an increased number of sequences from the families Adenoviridae and Picornaviridae (genus enterovirus). qRT-PCR/PCR confirmed the increased prevalence of adenoviruses and enteroviruses. Testing of additional diarrhea cohorts by qRT-PCR/PCR demonstrated statistically different prevalences in different geographic sites. These findings raise the question of whether the virome plays a role in enteric diseases and conditions that vary with geography.

dc.publisherReed Elsevier
dc.titleGeographic variation in the eukaryotic virome of human diarrhea
dc.typeJournal Article
dcterms.source.volume468
dcterms.source.startPage556
dcterms.source.endPage564
dcterms.source.issn0042-6822
dcterms.source.titleVirology
curtin.departmentSchool of Public Health
curtin.accessStatusOpen access via publisher


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record