Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Carotid Intima-Media thickness progression and risk of vascular events in people with Diabetes: Results from the PROG-IMT collaboration

    Access Status
    Open access via publisher
    Authors
    Lorenz, M.
    Price, J.
    Robertson, C.
    Bots, M.
    Polak, J.
    Poppert, H.
    Kavousi, M.
    Dorr, M.
    Stensland, E.
    Ducimetiere, P.
    Ronkainen, K.
    Kiechl, S.
    Sitzer, M.
    Rundek, T.
    Lind, L.
    Liu, J.
    Bergstrom, G.
    Grigore, L.
    Bokemark, L.
    Friera, A.
    Yanez, D.
    Bickel, H.
    Ikram, M.
    Volzke, H.
    Johnsen, S.
    Empana, J.
    Tuomainen, T.
    Willeit, P.
    Steinmetz, H.
    Desvarieux, M.
    Xie, W.
    Schmidt, C.
    Norata, Giuseppe
    Suarez, C.
    Sander, D.
    Hofman, A.
    Schminke, U.
    Mathiesen, E.
    Plichart, M.
    Kauhanen, J.
    Willeit, J.
    Sacco, R.
    McLachlan, S.
    Zhao, D.
    Fagerberg, B.
    Catapano, A.
    Gabriel, R.
    Franco, O.
    Bulbul, A.
    Scheckenbach, F.
    Pflug, A.
    Gao, L.
    Thompson, S.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lorenz, M. and Price, J. and Robertson, C. and Bots, M. and Polak, J. and Poppert, H. and Kavousi, M. et al. 2015. Carotid Intima-Media thickness progression and risk of vascular events in people with Diabetes: Results from the PROG-IMT collaboration. Diabetes Care. 38 (10): pp. 1921-1929.
    Source Title
    Diabetes Care
    DOI
    10.2337/dc14-2732
    ISSN
    0149-5992
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/55501
    Collection
    • Curtin Research Publications
    Abstract

    © 2015 by the American Diabetes Association. OBJECTIVE Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change to CVD events in people with diabetes. RESEARCH DESIGN AND METHODS In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 populationbased cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference inmean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis. RESULTS Average mean CCA-IMT ranged from 0.72 to 0.97mmacross cohorts in peoplewith diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between 20.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08). CONCLUSIONS Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.

    Related items

    Showing items related by title, author, creator and subject.

    • Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin?
      Liao, X.; Norata, Giuseppe; Polak, J.; Stehouwer, C.; Catapano, A.; Rundek, T.; Ezhov, M.; Sander, D.; Thompson, S.; Lorenz, M.; Balakhonova, T.; Safarova, M.; Grigore, L.; Empana, J.; Lin, H.; McLachlan, S.; Bokemark, L.; Ronkainen, K.; Schminke, U.; Lind, L.; Willeit, P.; Yanez, D.; Steinmetz, H.; Poppert, H.; Desvarieux, M.; Ikram, M.; Johnsen, S.; Iglseder, B.; Friera, A.; Xie, W.; Plichart, M.; Su, T.; Srinivasan, S.; Schmidt, C.; Tuomainen, T.; Völzke, H.; Nijpels, G.; Willeit, J.; Franco, O.; Suarez, C.; Zhao, D.; Ducimetiere, P.; Chien, K.; Robertson, C.; Bergström, G.; Kauhanen, J.; Dörr, M.; Dekker, J.; Kiechl, S.; Sitzer, M.; Bickel, H.; Sacco, R.; Hofman, A.; Mathiesen, E.; Gabriel, R.; Liu, J.; Berenson, G.; Kavousi, M.; Price, J. (2016)
      © 2016 European Society of Cardiology. Background The clinical use of carotid intima media thickness (cIMT) requires normal values, which may be subject to variation of geographical factors, ethnicity or measurement ...
    • Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration
      Lorenz, M.; Gao, L.; Ziegelbauer, K.; Norata, Giuseppe; Empana, J.; Schmidtmann, I.; Lin, H.; McLachlan, S.; Bokemark, L.; Ronkainen, K.; Amato, M.; Schminke, U.; Srinivasan, S.; Lind, L.; Okazaki, S.; Stehouwer, C.; Willeit, P.; Polak, J.; Steinmetz, H.; Sander, D.; Poppert, H.; Desvarieux, M.; Arfan Ikram, M.; Johnsen, S.; Staub, D.; Sirtori, C.; Iglseder, B.; Beloqui, O.; Engström, G.; Friera, A.; Rozza, F.; Xie, W.; Parraga, G.; Grigore, L.; Plichart, M.; Blankenberg, S.; Su, T.; Schmidt, C.; Tuomainen, T.; Veglia, F.; Völzke, H.; Nijpels, G.; Willeit, J.; Sacco, R.; Franco, O.; Uthoff, H.; Hedblad, B.; Suarez, C.; Izzo, R.; Zhao, D.; Wannarong, T.; Catapano, A.; Ducimetiere, P.; Espinola-Klein, C.; Chien, K.; Price, J.; Bergström, G.; Kauhanen, J.; Tremoli, E.; Dörr, M.; Berenson, G.; Kitagawa, K.; Dekker, J.; Kiechl, S.; Sitzer, M.; Bickel, H.; Rundek, T.; Hofman, A.; Mathiesen, E.; Castelnuovo, S.; Landecho, M.; Rosvall, M.; Gabriel, R.; de Luca, N.; Liu, J.; Baldassarre, D.; Kavousi, M.; de Groot, E.; Bots, M.; Yanez, D.; Thompson, S. (2018)
      Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high ...
    • Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population
      Baragetti, A.; Knoflach, M.; Cuccovillo, I.; Grigore, L.; Casula, M.; Garlaschelli, K.; Mantovani, A.; Wick, G.; Kiechl, S.; Willeit, J.; Bottazzi, B.; Catapano, A.; Norata, Giuseppe (2014)
      Background and aim: Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and, like C-reactive protein, is independently associated with the risk of developing vascular events. Aim of this ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.