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    Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population

    Access Status
    Fulltext not available
    Authors
    Baragetti, A.
    Knoflach, M.
    Cuccovillo, I.
    Grigore, L.
    Casula, M.
    Garlaschelli, K.
    Mantovani, A.
    Wick, G.
    Kiechl, S.
    Willeit, J.
    Bottazzi, B.
    Catapano, A.
    Norata, Giuseppe
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Baragetti, A. and Knoflach, M. and Cuccovillo, I. and Grigore, L. and Casula, M. and Garlaschelli, K. and Mantovani, A. et al. 2014. Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population. Nutrition, Metabolism and Cardiovascular Diseases. 24 (5): pp. 518-523.
    Source Title
    Nutrition, Metabolism and Cardiovascular Diseases
    DOI
    10.1016/j.numecd.2013.10.030
    ISSN
    0939-4753
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/56038
    Collection
    • Curtin Research Publications
    Abstract

    Background and aim: Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and, like C-reactive protein, is independently associated with the risk of developing vascular events. Aim of this study was to investigate, in two large population-based surveys, the Bruneck Study and the PLIC Study, whether PTX3 plasma levels predict the progression of common carotid artery intima-media thickness (CCA-IMT), a surrogate marker of atherosclerosis, in the general population during 5 or 6 years of follow-up. Results: In the Bruneck Study, PTX3 plasma levels did not predict a faster progression of CCA-IMT either in the carotid artery or in the femoral artery. This finding was confirmed in the PLIC Study where subjects within the highest tertile of PTX3 did not show an increased progression of CCA-IMT. PTX3 plasma levels were also not associated with the fastest maximum IMT progression. In summary, in more than 2400 subjects from the general population, PTX3 plasma level is neither an independent predictor of progression of subclinical atherosclerosis in different arterial territories, including carotid and femoral arteries nor of incident cardiovascular events. Conclusion: These findings support the relevance of investigating the predictive value of PTX3 plasma levels only in specific settings, like overt CVD, heart failure or acute myocardial infarction. © 2013 Elsevier B.V.

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