Case-control evaluation of the effectiveness of the G1P human rotavirus vaccine during an outbreak of rotavirus G2P infection in central Australia
MetadataShow full item record
Summary: The human rotavirus vaccine was evaluated during an outbreak of rotavirus G2P infection in central Australia. No overall protective effect against hospitalization was demonstrated, raising concerns over the durability of vaccine protection against heterotypic strains. Background: Two and a half years after commencing routine vaccination with human rotavirus vaccine, an outbreak of rotavirus G2P infection occurred in central Australia. Vaccine effectiveness against a P-containing strain (G9P ) had been demonstrated previously in this setting. This subsequent outbreak provided the opportunity to evaluate vaccine effectiveness against hospitalizations for a non-vaccine-related genotype in the same population. Methods: A case-control study was nested within a cohort of vaccine-eligible children listed on a populationbased immunization register. Children with rotavirus-confirmed gastroenteritis were individually matched by date of birth and Indigenous status with 4 control subjects. Results: Forty-one cases met the inclusion criteria, and 21 were severe cases among infants aged < 12 months. Nineteen (46%) of 41 case patients had received 2 doses of human rotavirus vaccine, compared with 87 (53%) of 164 control subjects. Vaccine effectiveness against rotavirus-related hospitalization was 19% (odds ratio,.81; 95% confidence interval,.32-2.05) for 2 doses compared with none. On secondary analysis, there was evidence of a protective effect against disease complicated by acidosis in the subset of infants aged < 12 months (odds ratio,.15; 95% confidence interval,.03-.84). Conclusions. Evidence was not found for an overall protective effect of human rotavirus vaccine against hospitalization for rotavirus disease in this setting. Post hoc analyses suggested a protective effect against severe disease in young infants. © The Author 2011.
Showing items related by title, author, creator and subject.
Modelling the co-occurence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tractJacoby, P.; Watson, K.; Bowman, J.; Taylor, A.; Riley, T.; Smith, D.; Lehmann, Deborah (2007)Go to ScienceDirect® Home Skip Main Navigation Links Brought to you by: The University of Western Australia Library Login: + Register Athens/Institution Login Not Registered? - User Name: Password: ...
Characterization of G2P rotavirus strains causing outbreaks of gastroenteritis in the Northern Territory, Australia, in 1999, 2004 and 2009Donato, C.; Cowley, D.; Donker, N.; Bogdanovic-Sakran, N.; Snelling, Thomas; Kirkwood, C. (2014)© 2014 Elsevier B.V. Outbreaks of rotavirus diarrhea cause a large disease burden in the Alice Springs region of the Northern Territory, Australia. The introduction of the rotavirus vaccine Rotarix® has been associated ...
Wu, Y.; Marsh, J.; McBryde, E.; Snelling, Thomas (2018)© 2018 Elsevier Ltd Background: Motivated by the unexplained variation in the performance of some vaccines across different settings, we extend previous theoretical work to consider the potential impact of incomplete case ...