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    Impact of systemic inflammation and autoimmune diseases on apoA-i and HDL plasma levels and functions

    Access Status
    Fulltext not available
    Authors
    Montecucco, F.
    Favari, E.
    Norata, Giuseppe
    Ronda, N.
    Nofer, J.
    Vuilleumier, N.
    Date
    2015
    Type
    Conference Paper
    
    Metadata
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    Citation
    Montecucco, F. and Favari, E. and Norata, G. and Ronda, N. and Nofer, J. and Vuilleumier, N. 2015. Impact of systemic inflammation and autoimmune diseases on apoA-i and HDL plasma levels and functions, pp. 455-482.
    Source Title
    Handbook of Experimental Pharmacology
    DOI
    10.1007/978-3-319-09665-0_14
    ISSN
    0171-2004
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/55637
    Collection
    • Curtin Research Publications
    Abstract

    © The Author(s) 2015. The cholesterol of high-density lipoproteins (HDLs) and its major proteic component, apoA-I, have been widely investigated as potential predictors of acute cardiovascular (CV) events. In particular, HDL cholesterol levels were shown to be inversely and independently associated with the risk of acute CV diseases in different patient populations, including autoimmune and chronic inflammatory disorders. Some relevant and direct anti-inflammatory activities of HDL have been also recently identified targeting both immune and vascular cell subsets. These studies recently highlighted the improvement of HDL function (instead of circulating levels) as a promising treatment strategy to reduce inflammation and associated CV risk in several diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In these diseases, anti-inflammatory treatments targeting HDL function might improve both disease activity and CV risk. In this narrative review, we will focus on the pathophysiological relevance of HDL and apoA-I levels/functions in different acute and chronic inflammatory pathophysiological conditions.

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