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dc.contributor.authorMontecucco, F.
dc.contributor.authorFavari, E.
dc.contributor.authorNorata, Giuseppe
dc.contributor.authorRonda, N.
dc.contributor.authorNofer, J.
dc.contributor.authorVuilleumier, N.
dc.date.accessioned2017-08-24T02:19:49Z
dc.date.available2017-08-24T02:19:49Z
dc.date.created2017-08-23T07:21:47Z
dc.date.issued2015
dc.identifier.citationMontecucco, F. and Favari, E. and Norata, G. and Ronda, N. and Nofer, J. and Vuilleumier, N. 2015. Impact of systemic inflammation and autoimmune diseases on apoA-i and HDL plasma levels and functions, pp. 455-482.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/55637
dc.identifier.doi10.1007/978-3-319-09665-0_14
dc.description.abstract

© The Author(s) 2015. The cholesterol of high-density lipoproteins (HDLs) and its major proteic component, apoA-I, have been widely investigated as potential predictors of acute cardiovascular (CV) events. In particular, HDL cholesterol levels were shown to be inversely and independently associated with the risk of acute CV diseases in different patient populations, including autoimmune and chronic inflammatory disorders. Some relevant and direct anti-inflammatory activities of HDL have been also recently identified targeting both immune and vascular cell subsets. These studies recently highlighted the improvement of HDL function (instead of circulating levels) as a promising treatment strategy to reduce inflammation and associated CV risk in several diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In these diseases, anti-inflammatory treatments targeting HDL function might improve both disease activity and CV risk. In this narrative review, we will focus on the pathophysiological relevance of HDL and apoA-I levels/functions in different acute and chronic inflammatory pathophysiological conditions.

dc.titleImpact of systemic inflammation and autoimmune diseases on apoA-i and HDL plasma levels and functions
dc.typeConference Paper
dcterms.source.volume224
dcterms.source.startPage455
dcterms.source.endPage482
dcterms.source.issn0171-2004
dcterms.source.titleHandbook of Experimental Pharmacology
dcterms.source.seriesHandbook of Experimental Pharmacology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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