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    Oligomerization and toxicity of Aß fusion proteins

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    Fulltext not available
    Authors
    Caine, J.
    Bharadwaj, Prashant
    Sankovich, S.
    Ciccotosto, G.
    Streltsov, V.
    Varghese, J.
    Date
    2011
    Type
    Journal Article
    
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    Citation
    Caine, J. and Bharadwaj, P. and Sankovich, S. and Ciccotosto, G. and Streltsov, V. and Varghese, J. 2011. Oligomerization and toxicity of Aß fusion proteins. Biochemical and Biophysical Research Communications. 409 (3): pp. 477-482.
    Source Title
    Biochemical and Biophysical Research Communications
    DOI
    10.1016/j.bbrc.2011.05.029
    ISSN
    0006-291X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/5565
    Collection
    • Curtin Research Publications
    Abstract

    This study has found that the Maltose binding protein Aß42 fusion protein (MBP-Aß42) forms soluble oligomers while the shorter MBP-Aß16 fusion and control MBP did not. MBP-Aß42, but neither MBP-Aß16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-Aß42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aß42 characterization. © 2011 .

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