Oligomerization and toxicity of Aß fusion proteins
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Authors
Caine, J.
Bharadwaj, Prashant
Sankovich, S.
Ciccotosto, G.
Streltsov, V.
Varghese, J.
Date
2011Type
Journal Article
Metadata
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This study has found that the Maltose binding protein Aß42 fusion protein (MBP-Aß42) forms soluble oligomers while the shorter MBP-Aß16 fusion and control MBP did not. MBP-Aß42, but neither MBP-Aß16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-Aß42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aß42 characterization. © 2011 .
Citation
Caine, J. and Bharadwaj, P. and Sankovich, S. and Ciccotosto, G. and Streltsov, V. and Varghese, J. 2011. Oligomerization and toxicity of Aß fusion proteins. Biochemical and Biophysical Research Communications. 409 (3): pp. 477-482.
Source Title
Biochemical and Biophysical Research Communications
Department
School of Biomedical Sciences