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dc.contributor.authorCaine, J.
dc.contributor.authorBharadwaj, Prashant
dc.contributor.authorSankovich, S.
dc.contributor.authorCiccotosto, G.
dc.contributor.authorStreltsov, V.
dc.contributor.authorVarghese, J.
dc.date.accessioned2017-01-30T10:47:05Z
dc.date.available2017-01-30T10:47:05Z
dc.date.created2015-10-29T04:08:41Z
dc.date.issued2011
dc.identifier.citationCaine, J. and Bharadwaj, P. and Sankovich, S. and Ciccotosto, G. and Streltsov, V. and Varghese, J. 2011. Oligomerization and toxicity of Aß fusion proteins. Biochemical and Biophysical Research Communications. 409 (3): pp. 477-482.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/5565
dc.identifier.doi10.1016/j.bbrc.2011.05.029
dc.description.abstract

This study has found that the Maltose binding protein Aß42 fusion protein (MBP-Aß42) forms soluble oligomers while the shorter MBP-Aß16 fusion and control MBP did not. MBP-Aß42, but neither MBP-Aß16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-Aß42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aß42 characterization. © 2011 .

dc.titleOligomerization and toxicity of Aß fusion proteins
dc.typeJournal Article
dcterms.source.volume409
dcterms.source.number3
dcterms.source.startPage477
dcterms.source.endPage482
dcterms.source.issn0006-291X
dcterms.source.titleBiochemical and Biophysical Research Communications
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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