Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    HDL in innate and adaptive immunity

    Access Status
    Open access via publisher
    Authors
    Catapano, A.
    Pirillo, A.
    Bonacina, F.
    Norata, Giuseppe
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Catapano, A. and Pirillo, A. and Bonacina, F. and Norata, G. 2014. HDL in innate and adaptive immunity. Cardiovascular Research. 103 (3): pp. 372-383.
    Source Title
    Cardiovascular Research
    DOI
    10.1093/cvr/cvu150
    ISSN
    0008-6363
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/55745
    Collection
    • Curtin Research Publications
    Abstract

    During infections or acute conditions high-density lipoproteins cholesterol (HDL-C) levels decrease very rapidly and HDL particles undergo profound changes in their composition and function. These changes are associated with poor prognosis following endotoxemia or sepsis and data from genetically modified animal models support a protective role for HDL. The same is true for some parasitic infections, where the key player appears to be a specific and minor component of HDL, namely apoL-1. The ability of HDL to influence cholesterol availability in lipid rafts in immune cells results in the modulation of toll-like receptors, MHC-II complex, as well as B- and T-cell receptors, while specific molecules shuttled by HDL such as sphingosine-1-phosphate (S1P) contribute to immune cells trafficking. Animal models with defects associated with HDL metabolism and/or influencing cell cholesterol efflux present features related to immune disorders. All these functions point to HDL as a platform integrating innate and adaptive immunity. The aim of this review is to provide an overview of the connection between HDL and immunity in atherosclerosis and beyond. © The Author 2014.

    Related items

    Showing items related by title, author, creator and subject.

    • The Cellular and Molecular Basis of Translational Immunometabolism
      Norata, Giuseppe; Caligiuri, G.; Chavakis, T.; Matarese, G.; Netea, M.; Nicoletti, A.; O'Neill, L.; Marelli-Berg, F. (2015)
      © 2015 Elsevier Inc. The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, ...
    • Immunofluorescent characterization of Non-Myelinating schwann cells and their interactions with immune cells in mouse mesenteric lymph node
      Shi, Z.; Greene, W.; Nicholls, P.; Hu, D.; Tirnitz-Parker, Nina; Yuan, Q.; Yin, C.; Ma, B. (2017)
      © Z. Shi et al., 2017 Licensee PAGEPress, Italy. The central nervous system (CNS) influences the immune system in a general fashion by regulating the systemic concentration of humoral substances, whereas the autonomic ...
    • Immune checkpoint inhibition: Prospects for prevention and therapy of hepatocellular carcinoma
      Elsegood, Caryn; Tirnitz-Parker, Nina; Olynyk, John; Yeoh, G. (2017)
      The global prevalence of liver cancer is rapidly rising, mostly as a result of the amplified incidence rates of viral hepatitis, alcohol abuse and obesity in recent decades. Treatment options for liver cancer are remarkably ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.