The application of supercritical CO<inf>2</inf> based technology for curcumin particle processing
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© 2016 Trans Tech Publications, Switzerland. Supercritical CO 2 is commonly used in the processing of natural products due to several advantageous factors such as inexpensiveness, moderate operating parameters and simple purification step. In the processing of phyto-pharmaceuticals, CO 2 has been used mostly for extraction, purification and particle formation. This article is a review of supercritical particle formation processes applied to phenolic compounds, specifically curcumin. In summary, supercritical technologies constitute a process platform for the modification of curcumin physicochemical properties. The use of supercritical CO 2 as a solute, solvent or anti-solvent in curcumin processing enabled the production of material with particle size as small as 15 nm and improved antioxidant activity.
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Kurniawansyah, F.; Mammucari, R.; Foster, Neil (2015)Inhalable dry formulations for pulmonary delivery of curcumin have been produced by supercritical antisolvent micronization. The antioxidant curcumin was co-processed with hydroxypropyl-beta-cyclodextrin (HP-ß-CD) and ...
Kurniawansyan, F.; Duong, H.; Danh, L.; Mammucari, R.; Vittorio, O.; Boyer, C.; Foster, Neil (2015)Inhalable formulations of curcumin with hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone have been produced by a newly developed anti-solvent micronization technique based on the supercritical fluid (SCF) technology. ...
Kurniawansyah, F.; Mammucari, R.; Foster, Neil (2017)© 2016 Elsevier B.V. Within the group of dense gas micronization processes, batch processes are attractive for the relative ease and cost-effectiveness of their scale-up. However, process parameters and product characteristics ...