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    Targeting platelets for the treatment of cancer

    254187.pdf (1.953Mb)
    Access Status
    Open access
    Authors
    Elaskalani, Omar
    Berndt, Michael
    Falasca, Marco
    Metharom, Pat
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Elaskalani, O. and Berndt, M. and Falasca, M. and Metharom, P. 2017. Targeting platelets for the treatment of cancer. Cancers. 9 (7): 94.
    Source Title
    Cancers
    DOI
    10.3390/cancers9070094
    ISSN
    2072-6694
    Faculty
    Faculty of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/56077
    Collection
    • Curtin Research Publications
    Abstract

    The majority of cancer-associated mortality results from the ability of tumour cells to metastasise leading to multifunctional organ failure and death. Disseminated tumour cells in the blood circulation are faced with major challenges such as rheological shear stresses and cell-mediated cytotoxicity mediated by natural killer cells. Nevertheless, circulating tumour cells with metastatic ability appear equipped to exploit host cells to aid their survival. Despite the long interest in targeting tumour-associated host cells such as platelets for cancer treatment, the clinical benefit of this strategy is still under question. In this review, we provide a summary of the latest mechanistic and clinical evidence to evaluate the validity of targeting platelets in cancer.

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