Pentraxins and atherosclerosis
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© 2012 Springer-Verlag/Wien. All rights are reserved. Pentraxins are a family of evolutionarily conserved multifunctional patternrecognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells and endothelial cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. Structural analysis and gene-modified mice have provided a new level of understanding of the role of pentraxins in immunity, inflammation and homeostasis. Unlike the classic short pentraxins CRP and SAP, whose sequence and regulation have diverged between mouse and man, PTX3 is highly conserved in man and mouse. Thus, results obtained using genetic approaches in the mouse are likely to be informative for the function of PTX3 in man, whereas extrapolation from animals to man is more difficult for CRP and SAP.
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Bonacina, F.; Baragetti, A.; Catapano, A.; Norata, Giuseppe (2013)Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and belongs, together with the C-reactive protein (CRP) and other acute phase proteins, to the pentraxins' superfamily: soluble, ...
Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregationBonacina, F.; Barbieri, S.; Cutuli, L.; Amadio, P.; Doni, A.; Sironi, M.; Tartari, S.; Mantovani, A.; Bottazzi, B.; Garlanda, C.; Tremoli, E.; Catapano, A.; Norata, Giuseppe (2016)© 2016 The Authors. Aim: The long pentraxin PTX3 plays a non-redundant role during acute myocardial infarction, atherosclerosis and in the orchestration of tissue repair and remodeling during vascular injury, clotting and ...
Norata, Giuseppe; Pirillo, A.; Ammirati, E.; Catapano, A. (2012)High density lipoproteins (HDL) possess a number of physiological activities. The most studied and, perhaps, better understood is the ability of HDL to promote excess cholesterol efflux from peripheral tissues and transport ...