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    Postprandial lipemia as a cardiometabolic risk factor

    Access Status
    Fulltext not available
    Authors
    Pirillo, A.
    Norata, Giuseppe
    Catapano, A.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Pirillo, A. and Norata, G. and Catapano, A. 2014. Postprandial lipemia as a cardiometabolic risk factor. Current Medical Research and Opinion. 30 (8): pp. 1489-1503.
    Source Title
    Current Medical Research and Opinion
    DOI
    10.1185/03007995.2014.909394
    ISSN
    0300-7995
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/56246
    Collection
    • Curtin Research Publications
    Abstract

    High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk. © 2014 Informa UK Ltd.

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