Show simple item record

dc.contributor.authorRabey, M.
dc.contributor.authorPoon, C.
dc.contributor.authorWray, J.
dc.contributor.authorThamajaree, C.
dc.contributor.authorEast, R.
dc.contributor.authorSlater, Helen
dc.date.accessioned2017-01-30T10:47:38Z
dc.date.available2017-01-30T10:47:38Z
dc.date.created2015-10-29T04:08:44Z
dc.date.issued2014
dc.identifier.citationRabey, M. and Poon, C. and Wray, J. and Thamajaree, C. and East, R. and Slater, H. 2014. Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects. Manual Therapy.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/5652
dc.identifier.doi10.1016/j.math.2015.02.011
dc.description.abstract

Background: People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in people with chronic low back pain (CLBP) may inform management. Objectives: To investigate pro/anti-nociceptive effects of a CPM protocol in age/sex-matched healthy controls (HCs) and people with CLBP. Design: Case-controlled trial (64 participants/group). Method: The CPM protocol involved: test stimulus (TS) (noxious pressure applied by algometer to lumbar region); conditioning stimulus (CS) (noxious heat applied by thermode to dorsal hand). CPM recruitment was measured by the change in pain intensity (rated on a numeric rating scale (NRS)) of the TS in the presence and absence of the CS. Results: Responses to this CPM protocol were variable for both groups with measures consistent with either inhibitory or facilitatory effects. A significantly greater proportion of facilitatory responses were seen in the CLBP cohort compared to HCs (73% versus 31%). In response to the CS, participants with CLBP demonstrated a mean increase in NRS scores (mean 1.3 points; p<0.001), while HCs did not (mean-0.2 points; p=0.35) and the between-group difference in change scores was significant (mean 1.4 points; p<0.001; effect size (Hedges' g): 1.03). Conclusion: In HCs and participants with CLBP this CPM protocol elicited responses consistent with varying pro/anti-nociceptive effects. The higher proportion of participants with CLBP demonstrating a facilitatory response suggests a pro-nociceptive phenotype may characterise this cohort.

dc.publisherChurchill Livingstone
dc.titlePro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects
dc.typeJournal Article
dcterms.source.issn1356-689X
dcterms.source.titleManual Therapy
curtin.departmentSchool of Physiotherapy and Exercise Science
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record