Myb via TGFβ is required for collagen type 1 production and skin integrity
dc.contributor.author | Sampurno, S. | |
dc.contributor.author | Cross, R. | |
dc.contributor.author | Pearson, H. | |
dc.contributor.author | Kaur, Pritinder | |
dc.contributor.author | Malaterre, J. | |
dc.contributor.author | Ramsay, R. | |
dc.date.accessioned | 2017-09-27T10:20:11Z | |
dc.date.available | 2017-09-27T10:20:11Z | |
dc.date.created | 2017-09-27T09:48:13Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Sampurno, S. and Cross, R. and Pearson, H. and Kaur, P. and Malaterre, J. and Ramsay, R. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors and Cytokines in Health and Disease. 33 (2): pp. 102-112. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/56640 | |
dc.identifier.doi | 10.3109/08977194.2015.1016222 | |
dc.description.abstract |
Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the architecture of the skin of avian myeloblastosis viral oncogene homolog (Myb) knock-out (KO) embryos and wound repair in Myb+/− mice revealing a need for Myb in the skin, attributed to fibroblast-dependent production of collagen type 1. Here, using targeted Myb deletion in keratin-14 (K14) positive cells we reveal further Myb-specific defects in epidermal cell proliferation, thickness and ultrastructural morphology. This was associated with a severe deficit in collagen type 1 production, reminiscent of that observed in patients with ichthyosis vulgaris and Ehlers–Danlos syndrome. Since collagen type 1 is a product of fibroblasts, the collagen defect observed was unexpected and appears to be directed by the loss of Myb with significantly reduced tumor growth factor beta 1 (Tgfβ−1) expression by primary keratinocytes. Our findings support a specific role for Myb in K14+ epithelial cells in the preservation of adult skin integrity and function. | |
dc.publisher | JAI Press | |
dc.title | Myb via TGFβ is required for collagen type 1 production and skin integrity | |
dc.type | Journal Article | |
dcterms.source.volume | 33 | |
dcterms.source.number | 2 | |
dcterms.source.startPage | 102 | |
dcterms.source.endPage | 112 | |
dcterms.source.issn | 1874-5687 | |
dcterms.source.title | Growth Factors and Cytokines in Health and Disease | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
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