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    Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells

    255642.pdf (19.97Mb)
    Access Status
    Open access
    Authors
    Caporale, C.
    Bader, C.
    Sorvina, A.
    Magee, K.
    Skelton, B.
    Gillam, T.
    Wright, P.
    Raiteri, Paolo
    Stagni, S.
    Morrison, J.
    Plush, S.
    Brooks, D.
    Massi, Massimiliano
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Caporale, C. and Bader, C. and Sorvina, A. and Magee, K. and Skelton, B. and Gillam, T. and Wright, P. et al. 2017. Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells. Chemistry - A European Journal. 23 (62): pp. 15666–15679.
    Source Title
    Chemistry - A European Journal
    DOI
    10.1002/chem.201701352
    ISSN
    0947-6539
    School
    Department of Chemistry
    Funding and Sponsorship
    http://purl.org/au-research/grants/arc/FT130100033
    http://purl.org/au-research/grants/arc/FT130100463
    Remarks

    This is the peer reviewed version of the following article: Caporale, C. and Bader, C. and Sorvina, A. and Magee, K. and Skelton, B. and Gillam, T. and Wright, P. et al. 2017. Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells. Chemistry - A European Journal. 23 (62): pp. 15666–15679, which has been published in final form at 10.1002/chem.201701352This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html

    URI
    http://hdl.handle.net/20.500.11937/56724
    Collection
    • Curtin Research Publications
    Abstract

    A family of five neutral cyclometalated iridium(III) tetrazolato complexes and their methylated cationic analogues have been synthesised and characterised. The complexes are distinguished by variations of the substituents or degree of p conjugation on either the phenylpyridine or tetrazolato ligands. The photophysical properties of these species have been evaluated in organic and aqueous media, revealing predominantly a solvatochromic emission originating from mixed metal-to-ligand and ligand-to-ligand charge transfer excited states of triplet multiplicity. These emissions are characterised by typically long excited-state lifetimes (~hundreds of ns), and quantum yields around 5-10% in aqueous media. Methylation of the complexes caused a systematic red-shift of the emission profiles. The behaviour and the effects of the different complexes were then examined in cells. The neutral species localised mostly in the endoplasmic reticulum and lipid droplets, whereas the majority of the cationic complexes localised in the mitochondria. The amount of complexes found within cells does not depend on lipophilicity, which potentially suggests diverse uptake mechanisms. Methylated analogues were found to be more cytotoxic compared to the neutral species, a behaviour that might to be linked to a combination of uptake and intracellular localisation.

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