Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system
MetadataShow full item record
Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and in vivo. In the associated research article  we generate multimodal polymeric nanoparticles functionalized with an antibody, that are designed to deliver an anti-oxidant to astrocytes. Here we provide additional data demonstrating the effects of the nanoparticle preparations on an indicator of oxidative stress in an immortalized Müller cell line in vitro. We provide data demonstrating the use of nanoscale secondary ion mass spectroscopy (NanoSIMS) to identify specific ions in bulk dried NP. NanoSIMS is also used to visualize 40Ca microdomains in the z dimension of optic nerve that has been subjected to a partial optic nerve transection. The associated article  describes the use of NanoSIMS to quantify 40Ca microdomains in optic nerve from animals treated with various nanoparticle preparations and provides further interpretation and discussion of the findings.
Showing items related by title, author, creator and subject.
Rajaeian, Babak (2012)Thin film composite (TFC) membranes have long been used by many large-scale applications (i.e., water and wastewater treatment). Recently, conventional polymeric TFC membranes are facing with short longevity due to high ...
Vellore Janarthanan, Mohanraj (2003)Delivery of complex molecules such as peptides, proteins, oligonucleotides and plasmids is an intensively studied subject, which has attracted considerable medical and pharmaceutical interest. Encapsulation of these ...
Murshidi, Julie Andrianny (2012)Concerns about the impact that fossil fuels have on the environment and their increasing price to the consumer have led to research being undertaken to evaluate and refine other energy carriers that will be comparable to ...