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dc.contributor.authorLozic, I.
dc.contributor.authorHartz, R.
dc.contributor.authorBartlett, C.
dc.contributor.authorShaw, J.
dc.contributor.authorArcher, M.
dc.contributor.authorNaidu, P.
dc.contributor.authorSmith, N.
dc.contributor.authorDunlop, S.
dc.contributor.authorSwaminathan Iyer, K.
dc.contributor.authorKilburn, M.
dc.contributor.authorFitzgerald, Melinda
dc.date.accessioned2017-09-27T10:21:05Z
dc.date.available2017-09-27T10:21:05Z
dc.date.created2017-09-27T09:48:16Z
dc.date.issued2016
dc.identifier.citationLozic, I. and Hartz, R. and Bartlett,, C. and Shaw, J. and Archer, M. and Naidu, P. and Smith, N. et al. 2016. Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system. Data in Brief. 7: pp. 152-156.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/56817
dc.identifier.doi10.1016/j.dib.2016.02.019
dc.description.abstract

Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and in vivo. In the associated research article [1] we generate multimodal polymeric nanoparticles functionalized with an antibody, that are designed to deliver an anti-oxidant to astrocytes. Here we provide additional data demonstrating the effects of the nanoparticle preparations on an indicator of oxidative stress in an immortalized Müller cell line in vitro. We provide data demonstrating the use of nanoscale secondary ion mass spectroscopy (NanoSIMS) to identify specific ions in bulk dried NP. NanoSIMS is also used to visualize 40Ca microdomains in the z dimension of optic nerve that has been subjected to a partial optic nerve transection. The associated article [1] describes the use of NanoSIMS to quantify 40Ca microdomains in optic nerve from animals treated with various nanoparticle preparations and provides further interpretation and discussion of the findings.

dc.publisherElsevier Inc.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCharacterization of polymeric nanoparticles for treatment of partial injury to the central nervous system
dc.typeJournal Article
dcterms.source.volume7
dcterms.source.startPage152
dcterms.source.endPage156
dcterms.source.titleData in Brief
curtin.departmentHealth Sciences Research and Graduate Studies
curtin.accessStatusOpen access


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