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    The role of phospholipase Cγ1 in breast cancer and its clinical significance

    Access Status
    Fulltext not available
    Authors
    Emmanouilidi, A.
    Lattanzio, R.
    Sala, G.
    Piantelli, M.
    Falasca, Marco
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Emmanouilidi, A. and Lattanzio, R. and Sala, G. and Piantelli, M. and Falasca, M. 2017. The role of phospholipase Cγ1 in breast cancer and its clinical significance. Future Oncology. 13 (22): pp. 1991-1997.
    Source Title
    Future Oncology
    DOI
    10.2217/fon-2017-0125
    ISSN
    1744-8301
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/56826
    Collection
    • Curtin Research Publications
    Abstract

    Breast cancer, the most common malignancy among women, is usually detected at an early stage and has a low risk of relapse. Nevertheless, a significant number of patients cannot be cured solely by local treatment. Distinguishing between patients who are of low risk of relapse from those who are of high risk may have important implications to improve treatment outcomes. The PLC-γ1 signaling pathway promotes many physiological processes, including cell migration and invasion. Increasing evidence shows aberrant PLC-γ1 signaling implication in carcinogenesis including breast cancer. In this review, the role of PLC-γ1 in breast cancer and its clinical implications will be discussed, as well as its potential as a prognostic factor and a therapeutic target.

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