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dc.contributor.authorEmmanouilidi, A.
dc.contributor.authorLattanzio, R.
dc.contributor.authorSala, G.
dc.contributor.authorPiantelli, M.
dc.contributor.authorFalasca, Marco
dc.identifier.citationEmmanouilidi, A. and Lattanzio, R. and Sala, G. and Piantelli, M. and Falasca, M. 2017. The role of phospholipase Cγ1 in breast cancer and its clinical significance. Future Oncology. 13 (22): pp. 1991-1997.

Breast cancer, the most common malignancy among women, is usually detected at an early stage and has a low risk of relapse. Nevertheless, a significant number of patients cannot be cured solely by local treatment. Distinguishing between patients who are of low risk of relapse from those who are of high risk may have important implications to improve treatment outcomes. The PLC-γ1 signaling pathway promotes many physiological processes, including cell migration and invasion. Increasing evidence shows aberrant PLC-γ1 signaling implication in carcinogenesis including breast cancer. In this review, the role of PLC-γ1 in breast cancer and its clinical implications will be discussed, as well as its potential as a prognostic factor and a therapeutic target.

dc.publisherFuture Medicine
dc.titleThe role of phospholipase Cγ1 in breast cancer and its clinical significance
dc.typeJournal Article
dcterms.source.titleFuture Oncology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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